Suggested modification of Janus associated kinase 2-tree algorithm for the detection of Janus associated kinase 2 V617F-positive polycythemia rubra vera patients in Pakistani population
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منابع مشابه
Megakaryocytic morphology in Janus kinase 2 V617F positive myeloproliferative neoplasm
CONTEXT Alterations in megakaryocyte morphology are the hallmark of myeloproliferative neoplasms (MPNs). These neoplasm are also associated with Janus kinase 2 (JAK2) V617F mutation in nearly 95% patients with polycythemia vera (PV), 40% patients of essential thrombocythemia (ET) and 50% patients of myelofibrosis (MF). The utility of megakaryocyte morphology in these disorders in correlation wi...
متن کاملJanus kinase 2 V617F mutation and thrombotic events in Behcet's disease: The Alexandria experience.
Behcet’s Disease (BD) is a rare, multisystem inflammatory disorder, which is relatively more common in the Mediterranean and East Asia, and is associated with considerable heterogeneity in its clinical course. Phenotypic difference among patients makes BD a difficult condition to diagnose and manage. However, vascular involvement is one of its common complications, with venous thrombosis being ...
متن کاملLimited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm.
Activation of Janus kinase 2 (JAK2), frequently as a result of the JAK2(V617F) mutation, is a characteristic feature of the classical myeloproliferative neoplasms (MPNs) polycythemia vera, essential thrombocythemia, and myelofibrosis, and it is thought to be responsible for the constitutional symptoms associated with these diseases. BMS-911543 is a JAK2-selective inhibitor that induces apoptosi...
متن کاملCorrelations between Janus Kinase 2 V617F Allele Burdens and Clinicohematologic Parameters in Myeloproliferative Neoplasms
BACKGROUND This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). METHODS Clinical and hematologic features were reviewed for 103 MPN patients, including patients with polycythemia vera (PV, 22 patients), essential thrombocythemia (ET, 64 patie...
متن کاملJanus Kinase 2 Polymorphisms Are Associated with Risk in Patients with Gastric Cancer in a Chinese Population
AIM To evaluate the impact of the Janus kinase 2 single nucleotide polymorphisms (SNPs) on gastric cancer risk. METHODS In this hospital-based, case-control study, the genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism protocols in 661 individuals (359 gastric cancer patients and 302 age and sex matched cancer-free controls). RESULTS Both the fre...
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ژورنال
عنوان ژورنال: Journal of Applied Hematology
سال: 2020
ISSN: 1658-5127
DOI: 10.4103/joah.joah_60_19